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HBV基因定量分析技术的应用价值、存在问题及展望--HBV基因定量分析技术的应用价值(3)
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| 文章出处：中国论文下载中心 发布时间：2005-11-11 |
六、HBV复制水平与抗病毒药物疗效之间的关系研究有待深入。笔者认为，HBV DNA水平与干扰素治疗效果之间的所谓联系在理论上缺乏根据，可能是一种表面现象，有必要探讨其本质。病毒复制水平高低取决于病毒自身的生物活性和机体的免疫功能，应当从病毒和机体两方面寻找突破口，提高干扰素抗HBV的效果。
最后，在中国，有世界上为数最众的HBV感染及相关慢性肝病患者，但我们在HBV感染诊治研究方面仍处于落后状态。就HBV定量技术而言，目前尚未建立分子杂交定量分析技术，现已报告的PCR定量分析法也属于低水平重复，今后有必要重视这方面的投资和开发。在临床研究领域应当有自己的立足点，不应简单重复国外研究结果。就HBV DNA定量分析意义的研究而言，简单重复的现象已不鲜见，必须引以为戒。
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